Two slices of a medium Domino's Deep Dish Pepperoni Pizza contains 780 calories, 37 grams of total fat, 15 grams of saturated fat and 1,940 mg of sodium.... Three slices of Domino's Hand Tossed Cheese Pizza without pepperoni has 516 calories, 14 grams of total fat, 6 grams of saturated fat and 1,470 mg of sodium.... Pepperoni and other processed meats are loaded with sodium.... Pepperoni is typically made with a mixture of fatty pork and beef, salt, spices and preservatives.... Both the pepperoni and the cheese on a pepperoni pizza contain unhealthy saturated fat.... Pepperoni pizza offers calcium and protein from cheese, vitamin-rich tomato sauce and carbohydrates, but the sodium and saturated fat are still serious drawbacks.... 36 percent of all pizza orders want their pizza topping pepperoni.... We consume around 251,770,000 pounds of pepperoni pizza every year.... The largest pizza ever made was at the Norwood Pick 'n Pay Hypermarket in Johannesburg, South Africa. According to the Guinness Book of Records the pizza was 37.4 meters in diameter and was made using 500 kg of flour, 800 kg of cheese and 900 kg of tomato puree. This was accomplished on December 8, 1990.... Each year in the United States, 3 billion pizzas are sold.... The highest-grossing single-unit independent pizzeria in the nation, Moose's Tooth Pub and Pizzeria, is in Anchorage , Alaska. Its annual sales are approximately $6 million.... Pizza comes from the latin root word Picea which means the blackening of crust by fire.... Each year, pizza is a $30 billion industry.... The world's fastest pizza maker can make 14 pizza in 2 minutes and 35 seconds.... About 3 billion pizzas are sold annually in the U.S.... Eating pizza once a week can reduce the risk of esophageal cancer.... The term pepperoni is a corruption of peperoni, the plural of peperone, the Italian word for pepper (the fruit, not the spice).... The first reference using pepperoni to refer to a sausage dates to 1919....